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FC0023
T cell receptor ζ chain
- T cell receptor ζ chain
Biological function
Antigen recognition of T cell receptor ζ-chains of immune cells results in the homo-oligomerization of the receptors through their
IDR cytoplasmic domains in T cell signalling.
Domain organization/sequence features
Cytoplasmic domains of antigen receptors contain one or more copies of immunoreceptor tyrosine-based activation motif
(ITAM), phosphorylation of which initiates the signaling cascade.
Structural evidence
Multimerization was confirmed by gel-filtration, ultracentrifugation, light-scattering and cross-linking. CD and NMR data support
the fully disordered state of the cytoplasmic domains, even in the oligomeric form.
Biochemical evidence
Although the interactions are weak, with KD values ranging from 10 mM to 1 mM, they are still required for cellular
activation that results in cytokine secretion.
Mechanism category
entropy tuning
Significance
Fuzziness of ζ chain contributes to rapid turnover and gradual phosphorylation events, which could take place even in
oligomeric form.
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