| Topology-based classification P - polymorphic: | | The disordered region folds into alternative structures upon binding to the same partner. | C - clamp: | | The fuzzy region serves as a dynamic linker between two structured binding regions. | F - flanking: | | The fuzzy region flanks the structured binding site/motif and remains dynamic. | R - random: | | The binding motifs, which are linked by fuzzy regions interchange in the bound form of the protein. | | | |
Mechanistic classification Conformational selection: The fuzzy region promotes the formation of a secondary structure element that is compatible/biased for binding.
Flexibility modulation: The fuzzy region modulates the binding entropy via transient interactions with the interface.
Tethering: The fuzzy region increases the local concentration of the binding element in the proximity of the partner (e.g. serves as an anchor).
Competitive binding: Intramolecular interactions of the fuzzy region compete with the intermolecular interactions of the binding element.
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