Topology-based classification

P - polymorphic:The disordered region folds into alternative structures upon binding to the same partner.
C - clamp:The fuzzy region serves as a dynamic linker between two structured binding regions.
F - flanking:The fuzzy region flanks the structured binding site/motif and remains dynamic.
R - random:The binding motifs, which are linked by fuzzy regions interchange in the bound form of the protein.

Mechanistic classification

Conformational selection:
The fuzzy region promotes the formation of a secondary structure element that is compatible/biased for binding.

Flexibility modulation:
The fuzzy region modulates the binding entropy via transient interactions with the interface.

Tethering:
The fuzzy region increases the local concentration of the binding element in the proximity of the partner (e.g. serves as an anchor).

Competitive binding:
Intramolecular interactions of the fuzzy region compete with the intermolecular interactions of the binding element.